Publications as an ASU faculty member
(*= corresponding author)
T. MacCulloch, N. Stephanopoulos*, “Proximity-enhanced synthesis of DNA-peptide-DNA triblock molecules” (submitted)
J. Bernal-Chanchavacǂ, M. Al-Aminǂ, N. Stephanopoulos*, “Nanoscale structures and materials from the self-assembly of polypeptides and DNA” (submitted; ǂ co-first authors)
C.R. Simmonsǂ, T. MacCullochǂ, M. Krepl, M. Matthies, A. Buchberger, I. Crawford, J. Sponer, P. Sulc, Y. Liu, N. Stephanopoulos*, H. Yan*, “A Comprehensive Structural and Computational Toolbox of Immobile Holliday Junctions for DNA-directed Self-assembly” (submitted; ǂ co-first authors)
A.P. Liu*, E. Appel, P. Ashby, B. Baker, E. Franco, L. Guo, K. Haynes, N. Joshi, A. Kloxin, P. Kouwer, J. Mittal, L. Morsut, V. Noireaux, S. Parekh, R. Schulman, S. Tang, M. Valentine, S. Vega, W. Weber, N. Stephanopoulos*, O. Chaudhuri*, “The ‘living interface’: a bridge between synthetic biology and biomaterial” (in revision; invited perspective/review for Nature Materials)
T. Yuan, Y. Shao, X. Zhou, Q. Liu, Z. Zhu, B. Zhou, Y. Dong, N. Stephanopoulos, S. Gui*, H. Yan*, D. Liu*, “Highly permeable DNA hydrogel promotes neurogenesis and functional recovery after completely transected spinal cord injury” (submitted)
B.I. Martinez, G. Mousa, K. Fleck, T. MacCulloch, C.W. Diehnelt, N. Stephanopoulos, S.E. Stabenfeldt*, “Uncovering temporally sensitive targeting domains for traumatic brain injury via phage display” (submitted) pre-print on bioRxiv
A. Buchberger, R.P. Narayanan, J. Bernal-Chanchavac, C.R. Simmons, K. Riker, N.E. Fahmi, R. Freeman, N. Stephanopoulos*, “Integrating proteins and DNA nanostructures using orthogonal coiled-coil peptides” (submitted)
R.P. Narayanan, A. Buchberger, L. Zhou, N.E. Fahmi, H. Yan, F. Zhang M.J. Webber*, N. Stephanopoulos*, “Supramolecular polymerization of DNA nanostructures using high-affinity host-guest interactions” (submitted)
A. Gangrade*, N. Stephanopoulos, D. Bhatia*, “Programmable, self-assembled DNA nanodevices for cellular programming and tissue engineering” (accepted)
“B. Smolková, T. MacCulloch, T. Rockwood, M. Liu, S.J.W. Henry, A. Frtús, M. Uzhytchak, M. Lunova, M. Hof, P. Jurkiewicz, A. Dejneka, N. Stephanopoulos*, O. Lunov*, “Effect of the protein corona on endosomal escape of functionalized DNA nanostructures” ACS Appl. Mater. Interfaces (accepted; ASAP online)
S.J.W. Henry, N Stephanopoulos*, “Functionalizing DNA nanostructures for therapeutic applications” Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. (2021) 13:e1729.
A. Buchbergerǂ, H. Sainiǂ, K.R. Eliatoǂ, R. Merkley, Y. Xu, A. Zare, J. Bernal, R. Ros*, M. Nikkhah*, N. Stephanopoulos*, “Reversible control of gelatin hydrogel stiffness using DNA crosslinkers” ChemBioChem (2021) 22:1755–1760. (ǂco-first authors)
N. Stephanopoulos*, P. Sulc, “DNA nanodevices as mechanical probes of protein structure and function” Appl. Sci. (2021) 11:2802.
C.R. Simmonsǂ, T. MacCullochǂ, F. Zhang, Y. Liu, N. Stephanopoulos*, H. Yan*, “A Self‐Assembled Rhombohedral DNA Crystal Scaffold with Tunable Cavity Sizes and High‐Resolution Structural Detail” Angew. Chem. Int. Ed. (2020) 59:18619-18626. (ǂco-first authors)
N. Stephanopoulos*, “Hybrid nanostructures from the self-assembly of proteins and DNA” Chem (2020) 6:364–405.
F.M. Fumasi, N. Stephanopoulos, J.L. Holloway*, “Reversible Control of Biomaterial Properties for Dynamically Tuning Cell Behavior” J. Appl. Polym. Sci. (2020) 137:e49058.
A. Buchberger, C.R. Simmons, N.E. Fahmi, R. Freeman, N. Stephanopoulos* "Hierarchical Assembly of Nucleic Acid/Coiled-Coil Peptide Nanostructures" J. Am. Chem. Soc. (2020) 3:1406-1416.
T. Mahatmanto*, I. Azizah, A, Buchberger, N. Stephanopoulos "Progress toward sourcing plants for new bioconjugation tools: a screening evaluation of a model peptide ligase using a synthetic precursor" 3 Biotech (2019) 9:442.
N. Stephanopoulos* "Peptide–Oligonucleotide Hybrid Molecules for Bioactive Nanomaterials" Bioconj. Chem. (2019) 30:1915-1922.
N. Stephanopoulos* "Strategies for stabilizing DNA nanostructures to biological conditions" ChemBioChem (2019) 20:2191-2197.
Y. Xu, S. Jiang, C. Simmons, R.P. Narayanan, F. Zhang, A.-M. Aziz, H. Yan, N. Stephanopoulos* “Tunable nanoscale cages from self-assembling DNA and protein building blocks” ACS Nano (2019) 13:3545–3554.
A. Stelson, M. Liu, C.A.E. Little, C.J. Long, N.D. Orloff, N. Stephanopoulos*, J.C. Booth* "Label-Free Detection of Conformational Changes in Switchable DNA Nanostructures with Microwave Microfluidics" Nat. Commun. (2019) 10:1174.
T. MacCulloch, A. Buchberger, N. Stephanopoulos* “ Emerging applications of peptide–oligonucleotide conjugates: bioactive scaffolds, self-assembling systems, and hybrid nanomaterials" Org. Biomol. Chem. (2019) 17:1668-1682.
M. Liu, S. Jiang, O. Loza, P. Sulc, N.E. Fahmi, N. Stephanopoulos* “Rapid Photoactuation of a DNA Nanostructure using an Internal Photocaged Trigger Strand" Angew. Chem. Int. Ed. (2018) 57:9341 –9345. (selected as paper for Wiley’s Joint Special Collection on Biopolymers, for the Murray Goodman Award Symposium at the 2019 ACS Spring Meeting: bit.ly/wileybiopolymers19)
C. Simmons, F. Zhang, T. MacCulloch, N.E. Fahmi, N. Stephanopoulos, Y. Liu, N. Seeman, H. Yan*, "Tuning the Cavity Size and Chirality of Self-Assembling 3D DNA Crystals” J. Am. Chem. Soc. (2017) 139:11254-11260.
D. Varun, G.R. Srinivaan, Y.-H. Tsai, H.-J. Kim, J. Cutts, F. Petty, R. Merkley, N. Stephanopoulos, D. Dolezalova, M. Marsala, D.A. Brafman*, “A Robust Vintronectin-Derived Peptide for the Scalable Long-term Expansion and Neuronal Differentiation of Human Pluripotent Stem Cell (hPSC)-derived Neural Progenitor Cells (hNPCs)” Acta Biomater. (2017) 48:120-130.
Publications prior to ASU
(* = co-first authors)
R. Freeman, M. Han, Z. Álvarez, J.A. Lewis, J.R. Wester, N. Stephanopoulos, M.T. McClendon, C. Lynsky, J.M. Godbe, H. Sangji, E. Luijten, S.I. Stupp, “Reversible self-assembly of superstructured networks” Science (2018) 362:808-813.
J.J. Greene, M.T. McClendon, N. Stephanopoulos, S.I. Stupp, C.-P. Richter, “Electrophysiological assessment of a peptide amphiphile nanofiber nerve graft for facial nerve repair” J. Tissue Eng. Regen. Med. (2018) 12:1389–1401.
A.J. Matsuoka , Z.A. Sayed, N. Stephanopoulos, E.J. Berns, A.R. Wadhwani, Z.D. Morrissey, D.M. Chadly, S. Kobayashi, A.N. Edelbrock, T. Mashimo, C.A. Miller, T.L. McGuire, S.I. Stupp, J.A. Kessler “Creating a stem cell niche in the inner ear using self-assembling peptide amphiphiles” PLoS ONE (2017) 12:e0190150.
R. Freeman*, N. Stephanopoulos*, Z. Álvarez, J.A. Lewis, S. Sur, C.M. Serrano, J. Boekhoven, S.S. Lee, S.I. Stupp, “Instructing cells with programmable DNA-peptide hybrids” Nat. Commun. (2017) 8:15982
C. Rubert-Perez, N. Stephanopoulos, S.S. Lee, S. C. Newcomb, Sur, S.I. Stupp, “The Powerful Functions of Peptide-Based Bioactive Matrices for Regenerative Medicine” (invited review) Ann. Biomed. Eng. (2015) 43:501-514.
N. Stephanopoulos, R. Freeman, H.N. Scheler, S. Sur, S. Jeong, F. Tantakitti, J.A. Kessler, S.I. Stupp, “Bioactive DNA-Peptide Nanotubes Enhance the Differentiation of Neural Stem Cells Into Neurons” Nano Lett. (2015) 15:603-609.
A. Li, A. Hokugo, A. Yalom, E.J. Berns, N. Stephanopoulos, M.T. McClendon, L.A. Segovia, I. Spigelman, S.I. Stupp, R. Jarrahy., “A bioengineered peripheral nerve construct using aligned peptide amphiphile nanofibers” Biomaterials (2014) 35:8780-8790.
N. Stephanopoulos, J.H. Ortony, S.I. Stupp, “Self-Assembly for the Synthesis of Functional Biomaterials” (invited review) Acta Materialia (2013) 61:912-930.
J. Sack, N. Stephanopoulos, D.C. Austin, M.B. Francis, J.S. Trimmer, “Antibody-guided photoablation of voltage-gated potassium channels” J. Gen. Physiol. (2013) 142:315-324.
N. Stephanopoulos, M.B. Francis, “Choosing an Effective Protein Bioconjugation Strategy.” (invited review) Nat. Chem. Biol. (2011) 7:876-884.
P.G. Holder, D.T. Finley, N. Stephanopoulos, R. Walton, D.S. Clark, M.B. Francis, “Dramatic Thermal Stability of Virus-Polymer Conjugates in Hydrophobic Solvents” Langmuir (2010) 26:17383–17388.
N. Stephanopoulos*, M. Liu*, G.J. Tong, Z. Li, Y. Liu, H. Yan, M.B. Francis, “Immobilization and One-Dimensional Arrangement of Virus Capsids with Nanoscale Precision Using DNA Origami” Nano Lett. (2010) 10:2714-2720.
R.A. Miller, N. Stephanopoulos, J.M. McFarland, A.S. Rosko, P.L. Geissler, M.B. Francis, “The Impact of Assembly State on the Defect Tolerance of TMV-based Light Harvesting Arrays” J. Am. Chem. Soc. (2010) 132:6068-6074.
N. Stephanopoulos, E.O.P. Solis, G. Stephanopoulos, “Nanoscale process systems engineering: Toward molecular factories, synthetic cells, and adaptive devices” (invited perspective) AIChE J. (2005) 51:1858-1869.
Invited book chapters
(*= corresponding author)
N. Stephanopoulos*, R. Freeman*, “DNA-based materials as self-assembling scaffolds for interfacing with cells”, “Self-Assembling Biomaterials: Molecular Design, Characterization and Application in Biology and Medicine, 1st Edition” 2018, pp. 157-175. (Elsevier)
L. Avolio, D. Sipes, N. Stephanopoulos, S. Sur*, “Recreating stem-cell niches using self-assembling biomaterials”, “Self-Assembling Biomaterials: Molecular Design, Characterization and Application in Biology and Medicine, 1st Edition” 2018, pp. 421-454. (Elsevier)
N. Stephanopoulos, M.B. Francis*, “Making New Materials from Viral Capsids”, “Polymer Science: A Comprehensive Reference, 1st Edition” 2012, Vol. 9, pp. 247-266. (Elsevier)