Stephanopoulos Lab

We work on the design, synthesis, and application of functional nanomaterials using self-assembling molecules from biology.

Contact Us

727 E. Tyler St., Tempe, AZ 85287

The Biodesign Institute, Room A120B

nstepha1@asu.edu 

480-727-3443

LAB MEMBERS

PROF. NICHOLAS STEPHANOPOULOS

 

Nick was born in Athens, Greece, but grew up outside of Boston, Massachusetts. He obtained his A.B. in chemistry from Harvard University, followed by a one-year stint to earn a Master’s in chemical engineering at MIT. He then pursued doctoral studies at the University of California, Berkeley, working with Prof. Matthew Francis. His research focused on using site-specific bioconjugation chemistry to modify viral capsid nano-scaffolds, in order to create materials for energy, biomedicine, and nanotechnology. After earning his PhD in 2010, he went to Northwestern University for postdoctoral studies, supported by both NIH Ruth Kirschtein and International Institute for Nanotechnology fellowships, working with Prof. Samuel Stupp on self-assembling peptide nanomaterials and their applications to regenerative medicine.

 

At both Berkeley and Northwestern, Nick became interested in integrating proteins and peptides with DNA nanotechnology. In 2015, he began his independent career at Arizona State University, with a goal to merge these molecules into a new class of hybrid nanomaterials, with applications across a range of fields. He is an assistant professor in the School of Molecular Sciences and the Biodesign Institute’s Center for Molecular Design and Biomimetics, and has affiliate appointments in Biomedical Engineering, Chemical Engineering, The Biomimicry Center, and the Global Security Initiative at ASU. Since coming to ASU, Nick has received the 2016 Air Force (AFOSR) Young Investigator Award, the 2018 Elsa U. Pardee Foundation Award for Cancer Research, the 2018 NSF CAREER Award, and the 2018 NIH New Innovator Award.

Email: nstepha1@asu.edu

Google Scholar Profile

Curriculum Vitae

Research scientists

NOUR EDDINE FAHMI

 

Nour Eddine received his PhD in Organic Chemistry from the Université de Picardie-Jules Verne,  France in 1996. He subsequently conducted postdoctoral research in the groups of Grahame Mackenzie (Hull, UK) and Sidney M. Hecht (University of Virginia). In 2002 he joined Pinnacle Pharmaceuticals as a Senior Scientist and was promoted to Director of Chemistry in 2007. In 2010, he moved to the Biodesign Institute at Arizona State University. He is interested in the synthesis and development of complex small molecules of biological relevance.

Email: noureddine.fahmi@asu.edu

Postdoctoral researchers

DR. YANG XU

 

Yang is from China and completed her Ph.D. Degree in Cell biology from the Peking Union Medical College in Beijing. She is especially interested in applying hybrid protein-DNA nanostructures, such as cages or fibers to cells, as well as incorporating unnatural amino acids into proteins for site-specific chemistry.

Email: yangxu3@asu.edu

DR. MINGHUI LIU

 

Minghui is from Wuhan, China. She received her bachelor's degree (2008) from Wuhan University, China and her doctorate degree (2013) from Arizona State University. Her previous research focused on DNA nanostructure-directed protein assembly, and currently she works on photo-actuation of DNA nanostructures, photo-switchable proteins, and DNA-protein hybrid nanostructures.

Email: mliu36@asu.edu

Graduate students

ALEX BUCHBERGER

 

Alex is from Brookfield, WI and completed his Bachelor’s degree in Chemistry at Winona State University in Minnesota. Alex’s research focuses on creating new nanomaterials out of peptide motifs (such as the coiled – coil) and DNA structures. When Alex isn’t in the lab he spends his time drinking (tea, of course) and watching Game of Thrones. #TheNorthRemembers
Email: abuchber@asu.edu

TARA MACCULLOCH

 

Tara is from Idaho and received her bachelor degree in chemistry from Boise State University in 2014.  Her research focuses on developing DNA-Peptide bioconjugates that can be utilized for cell delivery and incorporation of proteins into a DNA crystal lattice.  When she isn’t in the lab, Tara enjoys a good microbrew, attending concerts, and camping.
Email: tmaccull@asu.edu

RAGHU PRADEEP NARAYANAN

 

Raghu is from Chennai, India and did his integrated masters from University of Hyderabad, Hyderabad, India. His research interests are focused on using protein-DNA conjugates as a building blocks for novel nanostructures and machines. When Raghu is not in lab, he is either sleeping, reading politics, or watching Game of Thrones.
Email: rnaraya7@asu.edu

KIRSTIE SWINGLE

 

Kirstie is from New Mexico where she received a B.S. in biology from the University of New Mexico (2014). Her research focuses on designing genetic circuits responsive to protein signals for diagnostic design. In her free time, Kirstie likes dancing, reading, painting, music, and spending time outdoors.
Email: kswing21@gmail.com

FALLON FUMASI

 

Fallon (SEMTE, advisor: Prof. Julianne Holloway) was born and raised in the small town of Orland, California. She received her B.S. in Chemical Engineering with an emphasis in Biochemical Processes from Oregon State University in 2014 and her M.S. in Chemistry from the University of Oregon through the Advanced Materials Analysis and Characterization (AMAC) Program in 2015. She is fascinated in the development of new biomaterials for tissue engineering and regenerative medicine, particularly for orthopedic applications. In her free time, Fallon enjoys hunting, fishing, and playing softball or basketball.

Email: ffumasi@asu.edu

MD AL-AMIN

 

Alamin is from Bangladesh where he received his Bachelor in Chemistry and Masters in Inorganic and Analytical Chemistry from the University of Dhaka. His research interest are the de novo synthesis of proteins from synthetic peptides via native chemical ligation with DNA-templated reactions. When Alamin is not in the lab, he loves traveling, watching English TV series, Cricket and Football (Soccer) and hanging out with friends.

Email: malamin1@asu.edu

JULIO BERNAL

 

Julio is originally from Brookfield CT, where he received his bachelor's degree in chemistry, with a biochemistry focus, from Western Connecticut State University (WCSU) in 2018. His research interests include the use of novel DNA-Protein technology for use in the medical field, such as drug delivery and regenerative medicine. In his free time, he likes to spend his time playing bass, going on hikes, and seeing live music.
Email: jcbernal@asu.edu

Masters students

TYLER ROCKWOOD

 

Tyler is originally from Phoenix, Arizona and is currently a senior pursuing an undergraduate degree in medicinal biochemistry. His research interests include using protein and DNA structures to pursue new approaches to medicine delivery, as well as biological approaches to energy production.

Email: tfrockwo@asu.edu

Undergraduates

ADAM AKKAD

 

Adam is a first generation Syrian-American studying Medicinal Biochemistry at ASU. He plans on persuing an MD/PhD in Regenerative Medicine and Biomedical Engineering in the near future. His research interests are nano-materials and drug delivery and he is currently working on a project to redefine DNA nanotechnology by using the coiled-coil protein motif as well as DNA toconstruct hybrid nanostructures. In his free time, Adam likes to work on his 1991 Jeep Wrangler, hike, fish, go camping and play video games.
Email: rakkad@asu.edu

Lab alumni

BRITTANY FLORES  (4+1 Master's program)

OMAR LOZA  (4+1 Master's program)

RYAN MERKLEY  (4+1 Master's program)

ANN-MARIE AZIZ  (4+1 Master's program)

TIMOTHY LEE GRISWOLD  (4+1 Master's program)

ILYSSA CRAWFORD  (Undergraduate researcher)